Principles for modulation of the nuclear receptor superfamily

  title={Principles for modulation of the nuclear receptor superfamily},
  author={Hinrich Gronemeyer and Jan-{\AA}ke Gustafsson and Vincent Laudet},
  journal={Nature Reviews Drug Discovery},
Nuclear receptors are major targets for drug discovery and have key roles in development and homeostasis, as well as in many diseases such as obesity, diabetes and cancer. This review provides a general overview of the mechanism of action of nuclear receptors and explores the various factors that are instrumental in modulating their pharmacology. In most cases, the response of a given receptor to a particular ligand in a specific tissue will be dictated by the set of proteins with which the… CONTINUE READING
Highly Influential
This paper has highly influenced 25 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 390 extracted citations

Location of NLS-RARα protein in NB4 cell and nude mice

Oncology letters • 2017
View 7 Excerpts
Highly Influenced

TLX: An elusive receptor.

The Journal of steroid biochemistry and molecular biology • 2016
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 126 references

Rational design of RAR selective ligands revealed by RARβ crystal structure

P Germain
EMBO Rep • 2004

Synthetic retinoids and their nuclear receptors.

Current medicinal chemistry. Anti-cancer agents • 2004

Tumor suppressor IRF1 mediates retinoid and interferon anti-cancer signalling to death ligand TRAIL

N Clarke
EMBO J. 23, • 2004

from 25 ancestral genes to derived endocrine systems Mol

Bertrand, S. et al. Evolutionary genomics of nuclear receptors
Biol. Evol. 21, 1923–1937 • 2004

9 - cisretinoic acid capsules in the treatment of AIDS - related Kaposi sarcoma : results of a phase 2 multicenter clinical trial

G. Benoit
Arch . Dermatol . • 2003

Similar Papers

Loading similar papers…