Principles for modulation of the nuclear receptor superfamily

@article{Gronemeyer2004PrinciplesFM,
  title={Principles for modulation of the nuclear receptor superfamily},
  author={Hinrich Gronemeyer and Jan-{\AA}ke Gustafsson and Vincent Laudet},
  journal={Nature Reviews Drug Discovery},
  year={2004},
  volume={3},
  pages={950-964}
}
Nuclear receptors are major targets for drug discovery and have key roles in development and homeostasis, as well as in many diseases such as obesity, diabetes and cancer. This review provides a general overview of the mechanism of action of nuclear receptors and explores the various factors that are instrumental in modulating their pharmacology. In most cases, the response of a given receptor to a particular ligand in a specific tissue will be dictated by the set of proteins with which the… CONTINUE READING
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