Principles and Clinical Application of Assessing Alterations in Renal Elimination Pathways

@article{Tett2003PrinciplesAC,
  title={Principles and Clinical Application of Assessing Alterations in Renal Elimination Pathways},
  author={Susan E. Tett and Carl M. J. Kirkpatrick and Annette S. Gross and Andrew J McLachlan},
  journal={Clinical Pharmacokinetics},
  year={2003},
  volume={42},
  pages={1193-1211}
}
Drugs and metabolites are eliminated from the body by metabolism and excretion. The kidney makes the major contribution to excretion of unchanged drug and also to excretion of metabolites. Net renal excretion is a combination of three processes — glomerular filtration, tubular secretion and tubular reabsorption. Renal function has traditionally been determined by measuring plasma Creatinine and estimating Creatinine clearance. However, estimated Creatinine clearance measures only glomerular… CONTINUE READING

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