Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in Uganda.

@article{Dorsey2004PrincipalRO,
  title={Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in Uganda.},
  author={Grant Dorsey and Christian Dokomajilar and Moses Kiggundu and Sarah G. Staedke and Moses R. Kamya and Philip J. Rosenthal},
  journal={The American journal of tropical medicine and hygiene},
  year={2004},
  volume={71 6},
  pages={758-63}
}
Antimalarial resistance to sulfadoxine-pyrimethamine (SP) is mediated by mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes. However, the relative importance of different mutations is incompletely understood and has not been studied with combination therapy. Samples from 812 patients treated for uncomplicated malaria in Kampala, Uganda were tested for the presence of mutations commonly found in Africa. The dhps Glu-540 mutation was the strongest… CONTINUE READING