Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes.

@article{Chen2005PrincipalEO,
  title={Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes.},
  author={Kevin G Chen and Gergely Szak{\'a}cs and Jean-Philippe Annereau and François Rouzaud and Xing-Jie Liang and Julio C. Valencia and Chandrasekharam N. Nagineni and John J. Hooks and Vincent J. Hearing and Michael M. Gottesman},
  journal={Pigment cell research},
  year={2005},
  volume={18 2},
  pages={
          102-12
        }
}
ATP-binding cassette (ABC) transporters play a pivotal role in physiology and pathology. We identified and cloned two novel mRNA isoforms (ABCB 5alpha and ABCB 5beta) of the ABC transporter ABCB 5 in human melanoma cells. The deduced ABCB 5alpha protein appears to be an altered splice variant containing only a putative ABC, whereas the ABCB 5beta isoform shares approximately 70% similarity with ABCB1 (MDR1) and has a deduced topological arrangement similar to that of the whole carboxyl terminal… CONTINUE READING
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