Primordial germ cells of Xenopus embryos: The role of fibronectin in their adhesion during migration

@article{Heasman1981PrimordialGC,
  title={Primordial germ cells of Xenopus embryos: The role of fibronectin in their adhesion during migration},
  author={Janet Heasman and Richard O Hynes and A P Swan and V Thomas and Christopher C. Wylie},
  journal={Cell},
  year={1981},
  volume={27},
  pages={437-447}
}
Primordial germ cells (PGCs) of Xenopus laevis are highly migratory. The last section of their migratory pathway is through the dorsal mesentery of the tadpole gut. This in vivo pathway is rich in fibronectin, a glycoprotein that promotes cell adhesion and migration in vitro. Isolated PGCs are associated with cells from the mesentery and with fibronectin. Treatment with trypsin removes both the mesentery cells and the fibronectin. The PGCs do not appear to resynthesize detectable fibronectin in… CONTINUE READING

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