Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene.

@article{Brstle1992PrimitiveNT,
  title={Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene.},
  author={Oliver Br{\"u}stle and Hiroko Ohgaki and Horst Peter Schmitt and Gerhard F. Walter and Helmut Ostertag and Paul Kleihues},
  journal={Cancer},
  year={1992},
  volume={69 9},
  pages={2385-92}
}
Three patients had supratentorial malignant brain tumors 7 to 9 years after prophylactic central nervous system (CNS) treatment for acute lymphocytic leukemia or malignant T-cell lymphoma. Therapy was administered at the age of 3 to 8 years and included cranial irradiation (total dose, 1800 to 2400 cGy) and intrathecal methotrexate. The brain tumors had histologic and immunohistochemical features of primitive neuroectodermal tumors (PNET), including neuroblastic rosettes, rhythmic arrangement… CONTINUE READING

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