Primitive neuroectodermal tumors: ultrastructural and immunohistochemical studies.

  title={Primitive neuroectodermal tumors: ultrastructural and immunohistochemical studies.},
  author={Wielisław Papierz and Janusz Alwasiak and Paweł Kolasa and Zbigniew Węgrzyn and Krzysztof Marcin Zakrzewski and Lech Polis and Maria Debiec-Rychter and Pawel P. Liberski},
  journal={Ultrastructural pathology},
  volume={19 3},
We report here ultrastructural and immunohistochemical studies of neuroblastic differentiation in the retrospective (n = 17) and prospective (n = 26) series of primitive neuroectodermal tumors (PNETs). By electron microscopy, neuritelike structures containing parallel-oriented microtubules, adhesive plaque junctions, and pleomorphic dense-core vesicles were found in the majority of tumor specimens while synaptic specializations were very rare. By immunohistochemistry, synaptophysin appeared to… CONTINUE READING