Priming with secreted glycoprotein G of respiratory syncytial virus (RSV) augments interleukin-5 production and tissue eosinophilia after RSV challenge.

@article{Johnson1998PrimingWS,
  title={Priming with secreted glycoprotein G of respiratory syncytial virus (RSV) augments interleukin-5 production and tissue eosinophilia after RSV challenge.},
  author={Teresa R. Johnson and Joyce E. Johnson and Sharon R Roberts and Gail W. Wertz and Robert A. Parker and Barney S. Graham},
  journal={Journal of virology},
  year={1998},
  volume={72 4},
  pages={2871-80}
}
The respiratory syncytial virus (RSV) G glycoprotein promotes differentiation of type 2 CD4+ T lymphocytes and induces an eosinophilic response in lungs of RSV-infected mice. A unique feature of G is that a second initiation codon in the transmembrane region of the glycoprotein results in secretion of soluble protein from infected cells. Recombinant vaccinia viruses that express wild-type G (vvWT G), only secreted G (vvM48), or only membrane-anchored G (vvM48I) were used to define the influence… CONTINUE READING

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Immunological determinants of disease caused by respiratory syncytial virus

B. S. Graham
Trends Microbiol • 1996
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