Priming of the respiratory burst of bone marrow-derived macrophages is associated with an increase in protein kinase C content.

@article{Phillips1992PrimingOT,
  title={Priming of the respiratory burst of bone marrow-derived macrophages is associated with an increase in protein kinase C content.},
  author={Wayne A Phillips and M Croatto and John A Hamilton},
  journal={Journal of immunology},
  year={1992},
  volume={149 3},
  pages={1016-22}
}
The biochemical mechanism(s) underlying the priming of the macrophage for an enhanced PMA-induced respiratory burst is not understood. Because the cellular receptor for PMA is thought to be protein kinase C (PKC), we have investigated the effects of priming agents on cellular PKC levels. Sonicates from unprimed bone marrow-derived macrophages (BMM) were found to contain PKC activity (309 +/- 51 pmol 32P-incorporated/mg/min; mean +/- SE, n = 17) as measured by the phospholipid-, diacylglycerol… CONTINUE READING
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