Priming of the anterior pituitary with corticotropin-releasing hormone in vitro does not facilitate an ACTH response to interleukin-1 beta.

Abstract

Stimulation of the hypothalamo-pituitary-adrenal axis by the cytokine interleukin-1 beta (IL-1 beta) is an important facet of the functional interaction between the endocrine and immune systems. IL-1 beta can act by releasing corticotropin-releasing hormone (CRH) from the hypothalamus, but it has also been proposed to act directly at the anterior pituitary… (More)

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