Priming of microglia in a DNA-repair deficient model of accelerated aging

  title={Priming of microglia in a DNA-repair deficient model of accelerated aging},
  author={Divya D. A. Raj and Dick Jaarsma and Inge R Holtman and Marta Olah and Filipa M. Ferreira and Wandert Schaafsma and Nieske Brouwer and Michel M. Meijer and Monique C. de Waard and Ingrid van der Pluijm and Renata Brandt and Karim L. Kreft and Jon D Laman and Gerald de Haan and Knut Biber and Jan H. J. Hoeijmakers and Bart J.L. Eggen and Hendrikus W. G. M. Boddeke},
  journal={Neurobiology of Aging},
Aging is associated with reduced function, degenerative changes, and increased neuroinflammation of the central nervous system (CNS). Increasing evidence suggests that changes in microglia cells contribute to the age-related deterioration of the CNS. The most prominent age-related change of microglia is enhanced sensitivity to inflammatory stimuli, referred to as priming. It is unclear if priming is due to intrinsic microglia ageing or induced by the ageing neural environment. We have studied… CONTINUE READING