Priming of mesenchymal stem cells with oxytocin enhances the cardiac repair in ischemia/reperfusion injury.

  title={Priming of mesenchymal stem cells with oxytocin enhances the cardiac repair in ischemia/reperfusion injury.},
  author={Yong Sook Kim and Youngkeun Ahn and Jin Sook Kwon and Young Kuk Cho and Myung Ho Jeong and Jeong Gwan Cho and Jong Chun Park and Jung Kang},
  journal={Cells, tissues, organs},
  volume={195 5},
Oxytocin stimulates the cardiomyogenesis of embryonic stem cells and adult cardiac stem cells. We previously reported that oxytocin has a promigratory effect on umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs). In this study, UCB-MSCs were cultured with oxytocin and examined for their therapeutic effect in an infarcted heart. UCB-MSCs were pretreated with 100 nM oxytocin and cardiac markers were assessed by immunofluorescence staining. Next, oxytocin-supplemented USC-MSCs (OT-USCs… CONTINUE READING
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