Priming of human neutrophil respiratory burst by granulocyte/macrophage colony-stimulating factor (GM-CSF) involves partial phosphorylation of p47(phox).

@article{Dang1999PrimingOH,
  title={Priming of human neutrophil respiratory burst by granulocyte/macrophage colony-stimulating factor (GM-CSF) involves partial phosphorylation of p47(phox).},
  author={Pham My-Chan Dang and C{\'e}dric Dewas and Murielle Gaudry and Mich{\`e}le Fay and Eric P{\'e}druzzi and Marie Anne Gougerot-Pocidalo and Jamel El Benna},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 29},
  pages={20704-8}
}
Neutrophil superoxide production can be potentiated by prior exposure to "priming" agents such as granulocyte/macrophage colony stimulating factor (GM-CSF). Because the mechanism underlying GM-CSF-dependent priming is not understood, we investigated the effects of GM-CSF on the phosphorylation of the cytosolic NADPH oxidase components p47(phox) and p67(phox). Preincubation of neutrophils with GM-CSF alone increased the phosphorylation of p47(phox) but not that of p67(phox). Addition of formyl… CONTINUE READING

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