Priming of human CD4+ antigen-specific T cells to undergo apoptosis by HIV-infected monocytes. A two-step mechanism involving the gp120 molecule.

@article{Cottrez1997PrimingOH,
  title={Priming of human CD4+ antigen-specific T cells to undergo apoptosis by HIV-infected monocytes. A two-step mechanism involving the gp120 molecule.},
  author={Françoise Cottrez and Fabrizio Manca and Angus George Dalgleish and Fernando Arenzana-Seisdedos and Arnaud Capron and Herv{\'e} Groux},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={99 2},
  pages={257-66}
}
The study of the pathology of HIV-1 infection in chimpanzees supports the idea of the crucial role of HIV-infected monocytes in the pathogenesis of AIDS, although viral mechanisms that lead to T cell dysfunction and deletion during HIV infection are still unclear. We show here that HIV-1-infected antigen-presenting monocytes (APCs) are able to prime in vitro non-HIV-infected antigen-specific CD4+ T cell lines or peripheral blood CD4+ T cells to undergo apoptosis after antigen-specific… CONTINUE READING

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