Priming of calcium mobilization in human neutrophils by granulocyte-macrophage colony-stimulating factor: evidence for an involvement of phospholipase D-derived phosphatidic acid.

@article{Naccache1991PrimingOC,
  title={Priming of calcium mobilization in human neutrophils by granulocyte-macrophage colony-stimulating factor: evidence for an involvement of phospholipase D-derived phosphatidic acid.},
  author={Paul H. Naccache and Bernard Hamelin and Muriel Gaudry and Sylvain Bourgoin},
  journal={Cellular signalling},
  year={1991},
  volume={3 6},
  pages={635-44}
}
Human neutrophils pre-incubated with granulocyte-macrophage-colony-stimulating factor (GM-CSF) exhibit an enhanced mobilization of calcium in response to secondary stimuli such as chemotactic factors. The mechanisms underlying this priming effect of GM-CSF were examined. It was first demonstrated that the additional calcium mobilized by chemotactic factors… CONTINUE READING