Priming of CD4+ and CD8+ T cell responses using a HCV core ISCOMATRIX vaccine: a phase I study in healthy volunteers.

@article{Drane2009PrimingOC,
  title={Priming of CD4+ and CD8+ T cell responses using a HCV core ISCOMATRIX vaccine: a phase I study in healthy volunteers.},
  author={Debbie Drane and Eugene Maraskovsky and Rebecca April Gibson and Sue E Mitchell and Megan Barnden and Alan Moskwa and David Shaw and Barbara Gervase and Stephen A. Coates and Michael Houghton and Russel Basser},
  journal={Human vaccines},
  year={2009},
  volume={5 3},
  pages={151-7}
}
The disease burden and public health impact of chronic HCV infection continues to be a major problem globally. Current treatment for chronic HCV infection is not effective in all patients and is frequently associated with unacceptable side effects. Clearly a need exists for improved treatments and one such strategy is the use of therapeutic vaccines. Although still not completely understood, emerging data indicate that the generation of CD4(+) and CD8(+) T cells are important for the clearance… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Similar Papers

Loading similar papers…