Priming of CD4+ T cells and development of CD4+ T cell memory; lessons for malaria.

@article{Stephens2006PrimingOC,
  title={Priming of CD4+ T cells and development of CD4+ T cell memory; lessons for malaria.},
  author={Robin Stephens and Jean Langhorne},
  journal={Parasite immunology},
  year={2006},
  volume={28 1-2},
  pages={25-30}
}
CD4 T cells play a central role in the immune response to malaria. They are required to help B cells produce the antibody that is essential for parasite clearance. They also produce cytokines that amplify the phagocytic and parasitocidal response of the innate immune system, as well as dampening this response later on to limit immunopathology. Therefore, understanding the mechanisms by which T helper cells are activated and the requirements for development of specific, and effective, T cell… CONTINUE READING

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