Priming effects of substance P on calcium changes evoked by interleukin-8 in human neutrophils.

@article{Dianzani2001PrimingEO,
  title={Priming effects of substance P on calcium changes evoked by interleukin-8 in human neutrophils.},
  author={Chiara Dianzani and Giovanna Lombardi and Massimo Collino and Claudia Ferrara and M C Cassone and Roberto Fantozzi},
  journal={Journal of leukocyte biology},
  year={2001},
  volume={69 6},
  pages={1013-8}
}
The neurokinin (NK) substance P (SP), which is a mediator of neurogenic inflammation, has been reported to prime human polymorphonuclear neutrophils (PMNs). The priming effects of SP on PMNs activated by recombinant interleukin-8 (rIL-8) were investigated. SP enhanced, in a dose- and time-dependent way, the rise in cytosolic free-calcium concentration, [Ca(2+)]i, evoked by the chemokine. The priming effects of SP were abolished by exposing PMNs to a calcium-free medium supplemented with EGTA… CONTINUE READING

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