Priming and boosting immunity to respiratory syncytial virus by recombinant replication-defective vaccinia virus MVA.

@article{Wyatt1999PrimingAB,
  title={Priming and boosting immunity to respiratory syncytial virus by recombinant replication-defective vaccinia virus MVA.},
  author={Linda S. Wyatt and Stephen S. Whitehead and K A Venanzi and Brian R. Murphy and Bernard Moss},
  journal={Vaccine},
  year={1999},
  volume={18 5-6},
  pages={392-7}
}
Intranasal and intramuscular immunizations of mice with the highly attenuated MVA strain of vaccinia virus expressing the respiratory syncytial virus (RSV) F or G glycoprotein induced higher RSV antibody titers than those achieved by infection with RSV and greatly restricted the replication of RS challenge virus in both the upper and lower respiratory tracts. In addition, a recombinant MVA expressing both RSV F and G was stable and was as immunogenic as a combination of two single recombinant… CONTINUE READING

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