Priming Hepatitis B Surface ( HBsAg )-and Core Antigen ( HBcAg )-Specific Immune Responses by Chimeric , HBcAg with a HBsAg ‘ a ’ Determinant

Abstract

We developed an immunogen to stimulate multivalent immunity against hepatitis B surface antigen (HBsAg) and hepatitis B core antigens (HBcAg). Immune responses specific for both HBsAg and HBcAg play an important role in controlling the infection. HBsAg-specific antibodies mediate elimination of virions at an early stage of infection and prevent the spread… (More)

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