Primer: inflammasomes and interleukin 1β in inflammatory disorders

@article{Church2008PrimerIA,
  title={Primer: inflammasomes and interleukin 1$\beta$ in inflammatory disorders},
  author={Leigh D. Church and Graham P. Cook and Michael F. McDermott},
  journal={Nature Clinical Practice Rheumatology},
  year={2008},
  volume={4},
  pages={34-42}
}
Inflammasomes are large, multimeric protein complexes that link the sensing of microbial products and metabolic stress to the proteolytic processing of prointerleukin (pro-IL)-1β to its active form. NALP1 and NALP2 are founding members of the Nod-like receptor family. Other Nod-like receptors, including NALP3 and NOD2, which are associated with inflammatory disorders, have also been described. The NALP1 and NALP3 inflammasomes are located in the cytoplasm and can, therefore, detect… 

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