Primer: epigenetics of autoimmunity

@article{Richardson2007PrimerEO,
  title={Primer: epigenetics of autoimmunity},
  author={Bruce Richardson},
  journal={Nature Clinical Practice Rheumatology},
  year={2007},
  volume={3},
  pages={521-527}
}
Interactions between environmental and genetic factors are proposed to explain why autoimmunity afflicts certain individuals and not others. Genes and genetic loci predisposing to autoimmunity are being identified, but theories as to how the environment contributes to autoimmunity still rely largely on examples such as drug-induced systemic lupus erythematosus (SLE) and epidemiologic evidence of occupational exposure, without clear mechanistic explanations or identification of specific… CONTINUE READING