Primed polymorphonuclear leukocytes, oxidative stress, and inflammation antecede hypertension in the Sabra rat.

@article{Sela2004PrimedPL,
  title={Primed polymorphonuclear leukocytes, oxidative stress, and inflammation antecede hypertension in the Sabra rat.},
  author={Shifra Sela and Rafi Mazor and Mazal Amsalam and Chana Yagil and Yoram Yagil and Batya I Kristal},
  journal={Hypertension},
  year={2004},
  volume={44 5},
  pages={764-9}
}
Hypertension is accompanied by systemic oxidative stress, inflammation, and priming of peripheral polymorphonuclear leukocytes (PMNLs), yet the involvement of these factors in the pathophysiology of hypertension is incompletely understood. We investigated the relationship between oxidative stress, primed PMNLs, and inflammation and the development of hypertension in the Sabra rat model of salt-sensitive hypertension. Sabra hypertension-resistant rats (SBN/y) (salt-resistant) and Sabra… CONTINUE READING

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