Primed antigen-specific CD4+ T cells are required for NK cell activation in vivo upon Leishmania major infection.

@article{Bihl2010PrimedAC,
  title={Primed antigen-specific CD4+ T cells are required for NK cell activation in vivo upon Leishmania major infection.},
  author={Franck Bihl and Julien Pecheur and B{\'e}atrice Br{\'e}art and Gw{\'e}nola Poupon and Julie Cazareth and Val{\'e}rie Julia and Nicolas Glaichenhaus and V{\'e}ronique M Braud},
  journal={Journal of immunology},
  year={2010},
  volume={185 4},
  pages={2174-81}
}
The ability of NK cells to rapidly produce IFN-gamma is an important innate mechanism of resistance to many pathogens including Leishmania major. Molecular and cellular components involved in NK cell activation in vivo are still poorly defined, although a central role for dendritic cells has been described. In this study, we demonstrate that Ag-specific CD4(+) T cells are required to initiate NK cell activation early on in draining lymph nodes of L. major-infected mice. We show that early IFN… CONTINUE READING

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