Primed T cells are more resistant to Fas-mediated activation-induced cell death than naive T cells.

@article{Inaba1999PrimedTC,
  title={Primed T cells are more resistant to Fas-mediated activation-induced cell death than naive T cells.},
  author={Masaaki Inaba and Kazuhiro Kurasawa and Mizuko Mamura and Keiki Kumano and Yasushi Saito and Itsuo Iwamoto},
  journal={Journal of immunology},
  year={1999},
  volume={163 3},
  pages={1315-20}
}
Memory T cells respond in several functionally different ways from naive T cells and thus function as efficient effector cells. In this study we showed that primed T cells were more resistant to Fas-mediated activation-induced cell death (AICD) than naive T cells using OVA-specific TCR transgenic DO10 mice and Fas-deficient DO10 lpr/lpr mice. We found that apoptosis was efficiently induced in activated naive T cells at 48 and 72 h after Ag restimulation (OVA peptide; 0.3 and 3 microM), whereas… CONTINUE READING
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