Prime-boost using Separate Oncolytic Viruses in Combination with Checkpoint Blockade Improves Anti-tumor Therapy

@inproceedings{Ilett2017PrimeboostUS,
  title={Prime-boost using Separate Oncolytic Viruses in Combination with Checkpoint Blockade Improves Anti-tumor Therapy},
  author={Elizabeth J Ilett and Timothy J Kottke and Jill M Thompson and Karishma R. Rajani and S H Manzoor Zaidi and Laura Evgin and Matthew C. Coffey and Christy Ralph and Rosa Mar{\'i}a D{\'i}az and Hardev S. Pandha and Kevin J. Harrington and Peter John Selby and Richard J. Bram and Alan A Melcher and Richard G. Vile},
  booktitle={Gene Therapy},
  year={2017}
}
The anti-tumour effects associated with oncolytic virus therapy are mediated significantly through immune-mediated mechanisms, which depend both on the type of virus and the route of delivery. Here, we show that intra-tumoral oncolysis by Reovirus induced the priming of a CD8+, Th1-type anti-tumour response. By contrast, systemically delivered Vesicular Stomatitis Virus expressing a cDNA library of melanoma antigens (VSV-ASMEL) promoted a potent anti-tumour CD4+ Th17 response. Therefore, we… CONTINUE READING
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