Prime-boost: the way forward for recombinant vaccines against apicomplexan parasites. A Theileria perspective

Abstract

A good CD8+ response is required for immunity to many intracellular pathogens. Traditional antigen delivery using isolated sub-units or killed pathogens and adjuvant stimulates strong antibody responses but weak T-cell reactivity. Attenuated vaccines are usually more effective. The prime-boost delivery system based on immunisation with a naked DNA antigen–gene construct followed by boosting with an attenuated vaccinia virus expressing the same antigen is proving to be a powerful way to stimulate antigen-specific CD8 responses. Success using single epitopes is possible in malaria and we believe this approach holds much promise for other apicomplexan parasites such as Theileria spp.

DOI: 10.1007/s00436-001-0572-5

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@article{Hall2001PrimeboostTW, title={Prime-boost: the way forward for recombinant vaccines against apicomplexan parasites. A Theileria perspective}, author={R. Hall and Roger H. Adamson and Nicky Boulter}, journal={Parasitology Research}, year={2001}, volume={88}, pages={S45-S47} }