Prime-boost immunization with cruzipain co-administered with MALP-2 triggers a protective immune response able to decrease parasite burden and tissue injury in an experimental Trypanosoma cruzi infection model.

@article{Cazorla2008PrimeboostIW,
  title={Prime-boost immunization with cruzipain co-administered with MALP-2 triggers a protective immune response able to decrease parasite burden and tissue injury in an experimental Trypanosoma cruzi infection model.},
  author={Silvia In{\'e}s Cazorla and Fernanda Mar{\'i}a Frank and Pablo D Becker and Ricardo Santiago Corral and Carlos Alberto Guzm{\'a}n and Emilio L Malchiodi},
  journal={Vaccine},
  year={2008},
  volume={26 16},
  pages={
          1999-2009
        }
}
Cruzipain (Cz), a key Trypanosoma cruzi enzyme, is a main candidate antigen for vaccines against Chagas' disease. We evaluated a vaccination protocol based on intradermal priming with recombinant Cz and intranasal boosting with rCz co-administered with a derivative of the TLR2/6 agonist MALP-2. Vaccination triggered strong systemic and mucosal antibody responses, and a vigorous cell-mediated immunity characterized by lymphoproliferation, DTH reactivity and IFN-gamma production. The immune… CONTINUE READING

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