Prime-Boost Vaccination Using Chemokine-Fused gp120 DNA and HIV Envelope Peptides Activates Both Immediate and Long-Term Memory Cellular Responses in Rhesus Macaques

@inproceedings{Qin2010PrimeBoostVU,
  title={Prime-Boost Vaccination Using Chemokine-Fused gp120 DNA and HIV Envelope Peptides Activates Both Immediate and Long-Term Memory Cellular Responses in Rhesus Macaques},
  author={Hong Qin and Pramod N Nehete and Hong He and Bharti P. Nehete and Stephanie J. Buchl and Soung-chul Cha and Jagannadha K. Sastry and Larry W. Kwak},
  booktitle={Journal of biomedicine & biotechnology},
  year={2010}
}
HIV vaccine candidates with improved immunogenicity and induction of mucosal T-cell immunity are needed. A prime-boost strategy using a novel HIV glycoprotein 120 DNA vaccine was employed to immunize rhesus macaques. The DNA vaccine encoded a chimeric gp120 protein in fusion with monocyte chemoattractant protein-3, which was hypothesized to improve the ability of antigen-presenting cells to capture viral antigen through chemokine receptor-mediated endocytosis. DNA vaccination induced virus… CONTINUE READING