Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells

@article{Wang2014PrimatespecificER,
  title={Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells},
  author={Jichang Wang and Gangcai Xie and Manvendra Singh and Avazeh Tashakkori Ghanbarian and Tam{\'a}s Rask{\'o} and Attila Szvetnik and Huiqiang Cai and Daniel Besser and Alessandro Prigione and Nina V. Fuchs and Gerald G Schumann and Wei Chen and Matthew C. Lorincz and Zolt{\'a}n Ivics and Laurence D. Hurst and Zsuzsanna Izsv{\'a}k},
  journal={Nature},
  year={2014},
  volume={516},
  pages={405-409}
}
Naive embryonic stem cells hold great promise for research and therapeutics as they have broad and robust developmental potential. While such cells are readily derived from mouse blastocysts it has not been possible to isolate human equivalents easily, although human naive-like cells have been artificially generated (rather than extracted) by coercion of human primed embryonic stem cells by modifying culture conditions or through transgenic modification. Here we show that a sub-population… CONTINUE READING
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