Primate models of movement disorders of basal ganglia origin

  title={Primate models of movement disorders of basal ganglia origin},
  author={Mahlon R. Delong},
  journal={Trends in Neurosciences},
  • M. Delong
  • Published 1 July 1990
  • Medicine, Psychology
  • Trends in Neurosciences
Movement disorders associated with basal ganglia dysfunction comprise a spectrum of abnormalities that range from the hypokinetic disorders (of which Parkinson's disease is the best-known example) at one extreme to the hyperkinetic disorders (exemplified by Huntington's disease and hemiballismus) at the other. Both extremes of this movement disorder spectrum can be accounted for by postulating specific disturbances within the basal ganglia-thalamocortical 'motor' circuit. In this paper, Mahlon… Expand

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  • The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
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The model proposes that the purpose of the basal ganglia circuits is to select and inhibit specific motor synergies to carry out a desired action. Expand
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A dynamic activity model is proposed that disrupts balance between movement-related inhibition and surrounding excitation in the output nuclei, and induce motor symptoms in Parkinson's disease and dystonia. Expand
Functional anatomy of movement disorders
Models of basal ganglia function are described which encapsulate the principal pathophysiological mechanisms underlying parkinsonian akinesia on the one hand and abnormal involuntary movementExpand
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The basal ganglia (BG) have long been considered to play an important role in the control of movement and the pathophysiology of movement disorders, such as Parkinson's disease (PD). Studies over theExpand
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The basal ganglia are part of a neuronal network organized in parallel circuits that give rise to poverty and slowness of movement in Parkinson's disease or dyskinesias. Expand
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This chapter will briefly review the major anatomic features of the GABAergic pathways in the basal ganglia, and then describe in greater detail the changes of GABAergic transmission, which are known to occur in movement disorders. Expand
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Recent evidence indicating that a dopamine-induced dysbalance of basal ganglia neurocircuitries may be an important pathophysiological component in PD and schizophrenia is discussed. Expand
Pathological basal ganglia activity in movement disorders
This review critically summarize the current knowledge of the pathological discharge patterns of basal ganglia neurons in Parkinson's disease, dystonia, and dyskinesias. Expand
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A model in which specific types of basal ganglia disorders are associated with changes in the function of subpopulations of striatal projection neurons is proposed, which suggests that the activity of sub Populations of Striatal projections neurons is differentially regulated by striatal afferents and that different striatal projections may mediate different aspects of motor control. Expand
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The structure whose increase in LCMRg correlated most closely to the clinical severity of parkinsonism was the external segment of the globus pallidus. Expand