Primate defensins

  title={Primate defensins},
  author={R. Lehrer},
  journal={Nature Reviews Microbiology},
  • R. Lehrer
  • Published 2004
  • Medicine
  • Nature Reviews Microbiology
  • Defensins are endogenous, cysteine-rich antimicrobial peptides that contribute to host defence against bacterial, fungal and viral infections. There are three subfamilies of defensins in primates: α-defensins are most common in neutrophils and Paneth cells of the small intestine; β-defensins protect the skin and the mucous membranes of the respiratory, genitourinary and gastrointestinal tracts; and θ-defensins, which are expressed only in Old World monkeys, lesser apes and orangutans, are… CONTINUE READING
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