Primate-Specific ORF0 Contributes to Retrotransposon-Mediated Diversity

@article{Denli2015PrimateSpecificOC,
  title={Primate-Specific ORF0 Contributes to Retrotransposon-Mediated Diversity},
  author={A. Denli and I. Narvaiza and B. Kerman and Monique Pena and Christopher Benner and M. C. Marchetto and Jolene K. Diedrich and A. Aslanian and Jiao Ma and James J. Moresco and L. Moore and T. Hunter and A. Saghatelian and F. Gage},
  journal={Cell},
  year={2015},
  volume={163},
  pages={583-593}
}
  • A. Denli, I. Narvaiza, +11 authors F. Gage
  • Published 2015
  • Biology, Medicine
  • Cell
  • LINE-1 retrotransposons are fast-evolving mobile genetic entities that play roles in gene regulation, pathological conditions, and evolution. Here, we show that the primate LINE-1 5'UTR contains a primate-specific open reading frame (ORF) in the antisense orientation that we named ORF0. The gene product of this ORF localizes to promyelocytic leukemia-adjacent nuclear bodies. ORF0 is present in more than 3,000 loci across human and chimpanzee genomes and has a promoter and a conserved strong… CONTINUE READING
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