Primate CpG Islands Are Maintained by Heterogeneous Evolutionary Regimes Involving Minimal Selection

@article{Cohen2011PrimateCI,
  title={Primate CpG Islands Are Maintained by Heterogeneous Evolutionary Regimes Involving Minimal Selection},
  author={Netta Mendelson Cohen and Ephraim Kenigsberg and Amos Tanay},
  journal={Cell},
  year={2011},
  volume={145},
  pages={773-786}
}
Mammalian CpG islands are key epigenomic elements that were first characterized experimentally as genomic fractions with low levels of DNA methylation. Currently, CpG islands are defined based on their genomic sequences alone. Here, we develop evolutionary models to show that several distinct evolutionary processes generate and maintain CpG islands. One central evolutionary regime resulting in enriched CpG content is driven by low levels of DNA methylation and consequentially low rates of CpG… CONTINUE READING
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