Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci

@inproceedings{Hiratsuka2013PrimaryTM,
  title={Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci},
  author={Sachie Hiratsuka and Sachie Ishibashi and Takeshi Tomita and Akira Watanabe and Sachiko Akashi-Takamura and Masato Murakami and Hiroshi Kijima and Kensuke Miyake and Hiroyuki Aburatani and Yoshiro Maru},
  booktitle={Nature communications},
  year={2013}
}
In mouse models of lung metastasis, before the appearance of significant metastases, localized changes in vascular permeability have been observed, which appear to set the stage for tumour growth. However, it is unclear whether this is also true in human patients. Here, we show that MD-2, a coreceptor for Toll-like receptor 4 that has a key role in the… CONTINUE READING