Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized phase III trial.

@article{Aschele2011PrimaryTR,
  title={Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized phase III trial.},
  author={Carlo Aschele and Luca Cionini and Sara Lonardi and Carmine Pinto and Stefano Sergio Cordio and Gerardo Rosati and Salvatore Artale and Angiolo Tagliagambe and Giovanni Ambrosini and Paola Rosetti and Andrea Bonetti and Maria Emanuela Negru and Maria Chiara Tronconi and Gabriele Luppi and Giovanni Silvano and Domenico Cristiano Corsi and Anna Maria Bochicchio and Germana Chiaulon and Maurizio Gallo and Luca Boni},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2011},
  volume={29 20},
  pages={2773-80}
}
PURPOSE To investigate oxaliplatin combined with fluorouracil-based chemoradiotherapy as preoperative treatment for locally advanced rectal cancer. PATIENTS AND METHODS Seven hundred forty-seven patients with resectable, locally advanced (cT3-4 and/or cN1-2) adenocarcinoma of the mid-low rectum were randomly assigned to receive pelvic radiation (50.4 Gy in 28 daily fractions) and concomitant infused fluorouracil (225 mg/m(2)/d) either alone (arm A, n = 379) or combined with oxaliplatin (60 mg… CONTINUE READING
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