Primary tumor levels of human tissue kallikreins affect surgical success and survival in ovarian cancer patients.

@article{Dorn2007PrimaryTL,
  title={Primary tumor levels of human tissue kallikreins affect surgical success and survival in ovarian cancer patients.},
  author={Julia Dorn and Manfred Schmitt and R. Kates and Barbara Schmalfeldt and Marion Kiechle and Andreas Scorilas and Eleftherios P Diamandis and Nadia Harbeck},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2007},
  volume={13 6},
  pages={1742-8}
}
PURPOSE Proteolytic factors of the human tissue kallikrein (hK) family and the plasminogen activation system play a key role in tumor progression in various malignancies. We determined antigen levels of urokinase-type plasminogen activator (uPA), its inhibitor PAI-1, and hK5-8, hK10, hK11, and hK13 by ELISA in primary tumor tissue extracts of 142 International Federation of Gynecology and Obstetrics (FIGO) I to IV ovarian cancer patients (median follow-up 41 months). RESULTS After radical… CONTINUE READING
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