Primary treatment of Crohn’s disease: combined antibiotics taking center stage

@article{Chamberlin2011PrimaryTO,
  title={Primary treatment of Crohn’s disease: combined antibiotics taking center stage},
  author={William M. Chamberlin and Thomas J. Borody and Jordana Campbell},
  journal={Expert Review of Clinical Immunology},
  year={2011},
  volume={7},
  pages={751 - 760}
}
Although controversial, the use of properly chosen antibiotics in Crohn's disease appears beneficial. [] Key Method Relevant studies identified through a Medline search from 1976 to 2011 were assessed for inclusion by two independent observers who resolved any disagreements by consensus. References from all identified articles and recent review articles were cross-checked to ensure a thorough search. Papers were selected based on scientific merit as to which presented original contributions to the results.
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References

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A meta-analysis of broad-spectrum antibiotic therapy in patients with active Crohn's disease.
Preliminary Study of Ciprofloxacin in Active Crohn's Disease
TLDR
It is suggested that ciprofloxacin may be an effective agent when added to the treatment of moderately active, resistant CD and disease remission is defined as a decrease in the CDAI score to less than 150 points.
Long-term antibiotic treatment for Crohn's disease: systematic review and meta-analysis of placebo-controlled trials.
TLDR
Long-term treatment with nitroimidazoles or clofazimine appears to be effective in patients with Crohn's disease.
Antibiotic Therapy in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
TLDR
Antibiotic therapy may induce remission in active CD and UC, although the diverse number of antibiotics tested means the data are difficult to interpret.
Combined budesonide and antibiotic therapy for active Crohn's disease: a randomized controlled trial.
TLDR
In patients with active Crohn's disease of the ileum, the addition of ciprofloxacin and metronidazole to budesonide is an ineffective intervention, but this antibiotic combination may improve outcome when there is involvement of the colon.
Treatment of severe Crohn's disease using antimycobacterial triple therapy--approaching a cure?
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Use of antibiotics in the treatment of active Crohn's disease: experience with metronidazole and ciprofloxacin.
TLDR
Metronidazole and ciprofloxacin seem to be useful in treating active phases of Crohn's disease, and these results strongly support the important role of faecal flora in causing Cro bowel disease symptoms.
Antimycobacterial therapy in Crohn's disease: results of a controlled, double-blind trial with a multiple antibiotic regimen.
TLDR
This study suggests that the treatment regimen with rifampicin, ethambutol, clofazimine, and dapsone is effective in relief of symptoms and maintenance of remission in some Crohn's disease patients.
Is there a role for antibiotics as primary therapy in Crohn's ileitis?
TLDR
There is a need for a prospective controlled trial of ciprofloxacin or other antibiotics in active Crohn's ileitis, according to each patient, which had a dramatic improvement in abdominal pain and diarrhea coincident with the institution of cIProfl oxacin.
An antibiotic regimen for the treatment of active Crohn's disease: a randomized, controlled clinical trial of metronidazole plus ciprofloxacin.
OBJECTIVES Bacteria in the gut lumen may play a role in the etiology and/or the symptoms of Crohn's disease (CD). Although various antibacterial drugs have been employed in clinical practice, few…
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