Primary treatment of Crohn’s disease: combined antibiotics taking center stage
@article{Chamberlin2011PrimaryTO, title={Primary treatment of Crohn’s disease: combined antibiotics taking center stage}, author={William M. Chamberlin and Thomas J. Borody and Jordana Campbell}, journal={Expert Review of Clinical Immunology}, year={2011}, volume={7}, pages={751 - 760} }
Although controversial, the use of properly chosen antibiotics in Crohn's disease appears beneficial. [] Key Method Relevant studies identified through a Medline search from 1976 to 2011 were assessed for inclusion by two independent observers who resolved any disagreements by consensus. References from all identified articles and recent review articles were cross-checked to ensure a thorough search. Papers were selected based on scientific merit as to which presented original contributions to the results.
29 Citations
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Prolonged remission has been achieved for 3–23 years with individualised treatments, with the majority using AMAT ± infliximab and FMT.
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Putting Crohn’s on the MAP: Five Common Questions on the Contribution of Mycobacterium avium subspecies paratuberculosis to the Pathophysiology of Crohn’s Disease
- Medicine, BiologyDigestive Diseases and Sciences
- 2020
The authors hope that this discussion will stimulate further research aimed at confirming or refuting the contribution of MAP to the pathogenesis of Crohn’s disease and ultimately lead to advanced targeted clinical therapies.
Combining infliximab, anti-MAP and hyperbaric oxygen therapy for resistant fistulizing Crohn's disease
- MedicineFuture science OA
- 2015
Combining infliximab, hyperbaric oxygen therapy and anti-MAP seems to enable healing of recalcitrant fistulae and although a small case series, all nine patients achieved complete healing.
Resolution of Crohn’s (Johne’s) disease with antibiotics: what are the next steps?
- MedicineExpert review of gastroenterology & hepatology
- 2017
Observations indicate that infection with Map is similar to tuberculosis in which the majority of subjects infected with M. tuberculosis develop a protective immune response that controls but does not eliminate the pathogen.
The Changing Face of Inflammatory Bowel Disease: Etiology, Physiopathology, Epidemiology
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A multidisciplinary approach will soon be necessary, to face the tenacious behavior of IBD, on a global perspective.
Comment on 2018 ACG Clinical Guideline: Antibiotics in Crohn’s Disease
- Medicine, BiologyThe American Journal of Gastroenterology
- 2018
The ACG recently released the 2018 Guidelines for Crohn’s Disease are incorrect on several points regarding mycobacteria, according to a report published in the Annals of Internal Medicine.
Molecular analysis of sarcoidosis lymph nodes for microorganisms: a case–control study with clinical correlates
- Medicine, BiologyBMJ Open
- 2013
It is suggested that bacterial DNA-positive, symptomatic patients have more aggressive sarcoidosis that persists long term and might benefit from antimicrobial treatment directed against this presumed chronic granulomatous infection.
References
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OBJECTIVES
Bacteria in the gut lumen may play a role in the etiology and/or the symptoms of Crohn's disease (CD). Although various antibacterial drugs have been employed in clinical practice, few…