Primary systemic allergy to human insulin: recurrence of generalized urticaria after successful desensitization.

@article{Chng1995PrimarySA,
  title={Primary systemic allergy to human insulin: recurrence of generalized urticaria after successful desensitization.},
  author={H H Chng and K P Leong and Kenneth C Loh},
  journal={Allergy},
  year={1995},
  volume={50 12},
  pages={984-7}
}
Primary systemic allergy to human insulin is rare. We report a case of recurrent immediate local reactions followed eventually by generalized urticaria to recombinant human insulin (Humulin) in an insulin-dependent diabetic. Skin test to Humulin R was positive, and the patient was successfully desensitized using a modified rapid desensitization protocol. Two weeks later, he had another episode of generalized urticaria after Humulin R injection. His treatment was resumed at a lower dose, and… CONTINUE READING

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