Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes.

Abstract

The complete amino acid sequences of rat opioid receptors (designated as ROR-A and ROR-B) have been deduced by cloning and sequencing the cDNAs. The ligand-binding properties of ROR-A and ROR-B expressed from the cloned cDNAs in Chinese hamster ovary cells correspond most closely to those of the pharmacologically defined delta- and mu-opioid receptor subtypes, respectively. RNA blot hybridization analysis revealed that cerebrum and brainstem contain both ROR-A and ROR-B mRNAs, whereas neither ROR-A nor ROR-B mRNAs can be detected in cerebellum.

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@article{Fukuda1993PrimarySA, title={Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes.}, author={Kazuhiko Fukuda and Shingo Kato and K. J. Mori and Mayumi Nishi and Hideyuki Takeshima}, journal={FEBS letters}, year={1993}, volume={327 3}, pages={311-4} }