Primary structure of the immunoglobulin J chain from the mouse.

  title={Primary structure of the immunoglobulin J chain from the mouse.},
  author={Gordon M. Cann and Arieh Zaritsky and M. E. Koshland},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={79 21},
The primary structure of the murine J chain was investigated by sequence analysis of the J chain cDNA inserts from two independently cloned chimeric plasmids. The sequence data showed that (i) the two cDNA inserts accounted for all but approximately 100 5' nucleotides of the J chain mRNA and (ii) the J chain mRNA encodes a prepeptide of at least 23 amino acids, a mature protein of 137 residues, and an untranslated 3' region of 707 nucleotides exclusive of the 3' poly(A) tract. The amino acid… CONTINUE READING

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