Primary structure of the "hinge" region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit.

@article{Michaelsen1977PrimarySO,
  title={Primary structure of the "hinge" region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit.},
  author={T E Michaelsen and Blas Frangione and Edward C. Franklin},
  journal={The Journal of biological chemistry},
  year={1977},
  volume={252 3},
  pages={883-9}
}
The middle part of the heavy chain of IgG3 (hinge region) which covalently links the two gamma3 chains to each other, is about 4 times larger than the same region in the three other human IgG subclasses. This is probably due to a quadruplication of a 45-nucleotide DNA segment resulting in a gamma3 hinge region which is 62 amino acid residues long and consists of an NH2-terminal 17-residue segment followed by a 15-residue segment which is identically and consecutively repeated three times. The… CONTINUE READING
15 Citations
1 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.

Methods Enzymol

  • C. W. Hirs
  • 1967

Similar Papers

Loading similar papers…