Primary structure of human insulin‐like growth factor‐binding protein/placental protein 12 and tissue‐specific expression of its mRNA

  title={Primary structure of human insulin‐like growth factor‐binding protein/placental protein 12 and tissue‐specific expression of its mRNA},
  author={Mervi Julkunen and Riitta Koistinen and Katriina Aalto-Set{\"a}l{\"a} and Markku Seppälä and Olli A. J{\"a}nne and Kimmo K. Kontula},
  journal={FEBS Letters},
A low molecular weight insulin-like growth factor binding protein from rat: cDNA cloning and tissue distribution of its messenger RNA.
Rat serum contains two major forms of insulin-like growth factor (IGF) binding proteins (BPs) that have apparent mol wts of about 35,000 and 150,000. We have isolated a cDNA clone encoding an IGF-BP
Characterization and cloning of a bovine insulin-like growth factor-binding protein.
Proteins immunologically related to bovine IGFBP-2 were detected not only in sheep, but also in chickens, indicating that this IGFBP is not exclusively mammalian.
Cloning and sequence determination of bovine insulin‐like growth factor binding protein‐2 (IGFBP‐2): Comparison of its structral and functional properties with IGFBP‐1
The complete amino acid sequence of bovine IGFBP‐2 is reported and its functional properties are compared and its affinity for both forms of IGF is greater than for human IGF BP‐1.
The gene encoding human low-molecular weight insulin-like growth-factor binding protein (IGF-BP25): regional localization to 7p12–p13 and description of a DNA polymorphism
IGF-BP25 constitutes a useful genetic marker for the proximal short arm of chromosome 7, and is proposed to act as a paracrine regulator of cell growth.
Cloning of the rat insulin-like growth factor-binding protein-2 gene and identification of a functional promoter lacking a TATA box.
The IGFBP-2 gene lacks a TATA box immediately up-stream from the transcription initiation site and contains GC boxes that might be recognized by transcription factors Sp1 or ETF, but the promoter region contains multiple direct and indirect repeats.
Different tissue distribution and hormonal regulation of messenger RNAs encoding rat insulin-like growth factor-binding proteins-1 and -2.
It is demonstrated that expression of mRNAs encoding the two BPs differs in some fetal rat tissues and in the livers of adult rats after hypophysectomy, fasting, or streptozotocin-induced diabetes.
The fetal rat binding protein for insulin-like growth factors is expressed in the choroid plexus and cerebrospinal fluid of adult rats.
Examination of the expression of BP-3A in the rat central nervous system finds that it may facilitate the secretion of IGF-II to the cerebrospinal fluid and modulate its biological actions at distant sites within the brain.
Insulinlike growth factor-binding proteins.


Placental protein 12 is a decidual protein that binds somatomedin and has an identical N-terminal amino acid sequence with somatomedin-binding protein from human amniotic fluid.
Data show that PP12 is a somatomedin-binding protein and extend through previous literature on PP12 the existing knowledge on the physiology and pathophysiology of somatOMD protein(s) in human reproduction and cancer.
Insulin‐like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.
The complete primary structure of the human IGF‐I receptor from cloned cDNA is determined and the deduced sequence predicts a 1367 amino acid receptor precursor, including a 30‐residue signal peptide, which is removed during translocation of the nascent polypeptide chain.
An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.
It is concluded that a form of IGF binding protein that is present in extracellular fluids and is secreted by many types of cells can markedly potentiate the cellular response to IGF-I.
Soluble 34K binding protein inhibits the binding of insulin-like growth factor I to its cell receptors in human secretory phase endometrium: evidence for autocrine/paracrine regulation of growth factor action.
The results suggest that the 34K IGF-binding protein, secreted by the human endometrium in a cyclic fashion, has a significant role in inhibiting the receptor binding and, thus, the possible biological action of IGF-I in the endometrial in an autocrine/paracrine manner.
Isolation and characterization of a somatomedin-binding protein from mid-term human amniotic fluid.
The placenta radioreceptorassay for somatomedin can be used for detection of the binding protein, which has a high content of acidic/amidated residues and was isolated from human amniotic fluid by a three-step procedure.