Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence

@article{Noda1984PrimarySO,
  title={Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence},
  author={Masaharu Noda and Shin Shimizu and Tsutomu Tanabe and Toshiyuki Takai and Toshiaki Kayano and Takayuki Ikeda and Hideo Takahashi and Hitoshi Nakayama and Yuichi Kanaoka and Naoto Minamino and Kenji Kangawa and Hisayuki Matsuo and Michael A. Raftery and Tadaaki Hirose and S. Inayama and Hidenori Hayashida and Takashi Miyata and Shosaku Numa},
  journal={Nature},
  year={1984},
  volume={312},
  pages={121-127}
}
Cloning and sequence analysis of cDNA for the Electrophorus electricus electroplax sodium channel indicate that this protein, consisting of 1,820 amino acid residues, exhibits four repeated homology units, which are presumably oriented in a pseudosymmetric fashion across the membrane. Each homology unit contains a unique segment with clustered positively charged residues, which may be involved in the gating structure, possibly in conjunction with negatively charged residues clustered elsewhere. 
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