Primary structure and tissue distribution of the orphanin FQ precursor.

  title={Primary structure and tissue distribution of the orphanin FQ precursor.},
  author={H P Nothacker and Rainer K Reinscheid and Alfred Mansour and Robert A Henningsen and Ali Ardati and Frederick J. Monsma and Stanley J. Watson and Olivier Civelli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 16},
The heptadecapeptide orphanin FQ (OFQ) is a recently discovered neuropeptide that exhibits structural features reminiscent of the opioid peptides and that is an endogenous ligand to a G protein-coupled receptor sequentially related to the opioid receptors. We have cloned both the human and rat cDNAs encoding the OFQ precursor proteins, to investigate whether the sequence relationships existing between the opioid and OFQ systems are also found at the polypeptide precursor level, in particular… CONTINUE READING


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