Primary structure and high expression of human agrin in basement membranes of adult lung and kidney.

@article{Groffen1998PrimarySA,
  title={Primary structure and high expression of human agrin in basement membranes of adult lung and kidney.},
  author={Alexander J A Groffen and Carin Buskens and Toin H van Kuppevelt and Jacques H. Veerkamp and Leo Monnens and Lambert P. W. J. van den Heuvel},
  journal={European journal of biochemistry},
  year={1998},
  volume={254 1},
  pages={123-8}
}
Agrin is a heparan sulfate proteoglycan involved in the development of the neuromuscular junction during embryogenesis. In addition to this well-characterized function, agrin may have additional functions in other tissues and during other stages in development. In this study we present the cDNA sequence of human agrin, and demonstrate a high agrin content in adult basement membranes. The N-terminal domain of human agrin is highly similar to that of chick agrin, suggesting a similar function in… CONTINUE READING

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