Primary structure and functional characterization of rat C5a: an anaphylatoxin with unusually high potency.

@article{Cui1994PrimarySA,
  title={Primary structure and functional characterization of rat C5a: an anaphylatoxin with unusually high potency.},
  author={L H Cui and D F Carney and Tony E. Hugli},
  journal={Protein science : a publication of the Protein Society},
  year={1994},
  volume={3 8},
  pages={1169-77}
}
The anaphylatoxin C5a is a pro-inflammatory factor generated from C5 during complement activation. C5a derived from rat C5 exhibits significantly greater potency compared to C5a from other species. Rat C5a was 25-fold more potent than human C5a for eliciting spasmogenic contraction of guinea pig ileum. Proteolytic removal of the C-terminal arginine of C5a (C5adesArg) reduced spasmogenic potency of rat C5a by only 4-fold compared to a 3,000-fold reduction for human C5adesArg. In addition, rat… CONTINUE READING