Primary structure and expression of a sodium channel characteristic of denervated and immature rat skeletal muscle

@article{Kallen1990PrimarySA,
  title={Primary structure and expression of a sodium channel characteristic of denervated and immature rat skeletal muscle},
  author={R. Kallen and Z. Sheng and Jane Yang and Liquiong Chen and R. Rogart and R. Barchi},
  journal={Neuron},
  year={1990},
  volume={4},
  pages={233-242}
}
The alpha subunit of a voltage-sensitive sodium channel characteristic of denervated rat skeletal muscle was cloned and characterized. The cDNA encodes a 2018 amino acid protein (SkM2) that is homologous to other recently cloned sodium channels, including a tetrodotoxin (TTX)-sensitive sodium channel from rat skeletal muscle (SkM1). The SkM2 protein is no more homologous to SkM1 than to the rat brain sodium channels and differs notably from SkM1 in having a longer cytoplasmic loop joining… Expand
TTX-sensitive and TTX-insensitive sodium channel mRNA transcripts are independently regulated in adult skeletal muscle after denervation
TLDR
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Expression of the sodium channel β 1 subunit in rat skeletal muscle is selectively associated with the tetrodotoxin-sensitive α subunit isoform
Abstract Transcripts homologous to the rat brain sodium channel β subunit ( β 1 ) are prominently expressed in both innervated and denervated adult skeletal muscle and in heart, but not in neonatalExpand
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The cloning and nucleotide sequence determination of the normal product of the SCN4A gene product is reported, which is the human homologue of rSkM1, the tetrodotoxin‐sensitive sodium channel characteristic of adult rat skeletal muscle. Expand
Regulation of muscle sodium channel transcripts during development and in response to denervation.
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Primary structure and functional expression of a developmentally regulated skeletal muscle chloride channel
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expression from cRNA in Xenopus oocytes leads to 9-anthracene-carboxylic acid-sensitive currents with time and voltage dependence typical for macroscopic muscle Cl− conductance, and the functional destruction of this channel in mouse myotonia suggests that the major skeletal muscle chloride channel is cloned. Expand
Sodium Channel mRNAs at the Neuromuscular Junction: Distinct Patterns of Accumulation and Effects of Muscle Activity
TLDR
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The tetrodotoxin-insensitive sodium current in rat dorsal root ganglia is unlikely to involve the expression of the tetrodotoxin-resistant sodium channel, SkM2
TLDR
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TLDR
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Sodium Channel NaV1.5 Expression is Enhanced in Cultured Adult Rat Skeletal Muscle Fibers
TLDR
The FDB model is a useful tool to study the effects of denervation in adult muscle fibers in vitro and the expression of sodium channels, and the involvement of β subunits in the regulation of sodium current and fiber excitability. Expand
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TLDR
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