Primary structure and biological activity of a novel human neurotrophic factor

  title={Primary structure and biological activity of a novel human neurotrophic factor},
  author={Arnon Rosenthal and David Norman Van Goeddel and T. Nguyen and Martyn Lewis and Ai Shih and Gary R. Laramee and K{\'a}roly Nikolics and John W. Winslow},
The pharmacological potential of neurotrophins: A perspective
  • G. Vantini
  • Biology, Medicine
  • 1992
Human nerve growth factor: biological and immunological activities, and clinical possibilities in neurodegenerative disease.
The release of these proteins is believed to regulate not only the survival of neurons but also the timing and and exent of innervation of the target tissues.
Primary structure and biological activity of human brain-derived neurotrophic factor.
Brain-derived neurotrophic factor has been shown to promote the survival of neurons located in or directly connected with the CNS and is likely to function in adjusting the cell number within neuronal populations to the need of this projection field.
Neurotrophic factors: from physiology to pharmacology?
Identification and Characterization of a Novel Neurotrophic Factor Secreted by a Mouse Schwann Cell Line by
It is concluded that the trophic factors secreted by MS1 cells from an immortalized Schwann cell line is a novel and specific survival factor for dopaminergic neurons.
Functional interactions of neurotrophins and neurotrophin receptors.
The number of neurons in the adult nervous system and the density of innervation of their targets are determined by a competitive process in which tissues produce trophic factors that support neuronal survival.
Neurotrophic factors and neurologic disease.
The progress in defining neurotrophic factors and their receptors and in characterizing their actions are reviewed and how neurotrophic factor could be implicated in the pathogenesis of neurologic disorders is discussed.


Molecular cloning and expression of brain-derived neurotrophic factor
The full primary structure of brain-derived neurotrophic factor is reported and it is established that these two neurotrophic factors are related both functionally and structurally.
Purification of a new neurotrophic factor from mammalian brain.
This factor is the first neurotrophic factor to be purified since NGF, from which it is clearly distinguished because it has different antigenic and functional properties.
Expression of the beta-nerve growth factor gene correlates with the density of sympathetic innervation in effector organs.
  • D. Shelton, L. Reichardt
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1984
Levels of NGF mRNA were found that are too high to be attributed entirely to the vasculature, suggesting a role for NGF in adult central nervous system function.
Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
  • F. Hefti
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1986
It is suggested that fimbrial transections resulted in retrograde degeneration of cholinergic septo-hippocampal neurons and that NGF treatment strongly attenuated this lesion-induced degeneration.
Nerve growth factor in sympathetic ganglia and corresponding target organs of the rat: correlation with density of sympathetic innervation.
  • S. Korsching, H. Thoenen
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1983
A two-site enzyme immunoassay is described which does not suffer from artifacts inherent in previous assays and has the necessary high sensitivity to determine the endogenous levels of nerve growth
Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.
  • L. Greene, A. Tischler
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1976
A single cell clonal line which responds reversibly to nerve growth factor (NGF) has been established from a transplantable rat adrenal pheochromocytoma and should be a useful model system for neurobiological and neurochemical studies.
Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways.
A new family of protein kinase C-related genes has been identified in bovine, human, and rat genomes that are highly homologous, include a kinase domain, and potential calcium-binding sites, and they contain interspersed variable regions.
Development of the peripheral nervous system from the neural crest.
The neural crest, which originates from the lateral ridges of the neural primordium in the Vertebrate embryo, constitutes a useful model for the study of a number of important developmental