Primary structure and biological activity of a novel human neurotrophic factor

@article{Rosenthal1990PrimarySA,
  title={Primary structure and biological activity of a novel human neurotrophic factor},
  author={Arnon Rosenthal and David Norman Van Goeddel and T. Nguyen and Martyn Lewis and Ai Shih and Gary R. Laramee and K{\'a}roly Nikolics and John W. Winslow},
  journal={Neuron},
  year={1990},
  volume={4},
  pages={767-773}
}
The pharmacological potential of neurotrophins: A perspective
  • G. Vantini
  • Biology, Medicine
    Psychoneuroendocrinology
  • 1992
Human nerve growth factor: biological and immunological activities, and clinical possibilities in neurodegenerative disease.
TLDR
The release of these proteins is believed to regulate not only the survival of neurons but also the timing and and exent of innervation of the target tissues.
Primary structure and biological activity of human brain-derived neurotrophic factor.
TLDR
Brain-derived neurotrophic factor has been shown to promote the survival of neurons located in or directly connected with the CNS and is likely to function in adjusting the cell number within neuronal populations to the need of this projection field.
Neurotrophic factors: from physiology to pharmacology?
Identification and Characterization of a Novel Neurotrophic Factor Secreted by a Mouse Schwann Cell Line by
TLDR
It is concluded that the trophic factors secreted by MS1 cells from an immortalized Schwann cell line is a novel and specific survival factor for dopaminergic neurons.
Functional interactions of neurotrophins and neurotrophin receptors.
TLDR
The number of neurons in the adult nervous system and the density of innervation of their targets are determined by a competitive process in which tissues produce trophic factors that support neuronal survival.
Neurotrophic factors and neurologic disease.
TLDR
The progress in defining neurotrophic factors and their receptors and in characterizing their actions are reviewed and how neurotrophic factor could be implicated in the pathogenesis of neurologic disorders is discussed.
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