Primary structure, chromosomal localization, and functional expression of a voltage-gated sodium channel from human brain.

@article{Ahmed1992PrimarySC,
  title={Primary structure, chromosomal localization, and functional expression of a voltage-gated sodium channel from human brain.},
  author={C. M. Iqbal Ahmed and Doreen H Ware and Stephen C. Lee and Craig D. Patten and Antonio V. Ferrer-Montiel and Alejandro F Schinder and John D. McPherson and Caryn B Wagner-McPherson and John Jacob Wasmuth and G. A. Evans},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 17},
  pages={
          8220-4
        }
}
A cDNA library derived from human cerebral cortex was screened for the presence of sodium channel alpha subunit-specific clones. Ligation of three overlapping clones generated a full-length cDNA clone, HBA, that provided the complete nucleotide sequence coding for a protein of 2005 amino acids. The predicted structure suggests four homologous repeats and exhibits greatest homology and structural similarity to the rat brain sodium channel II. A second cDNA clone, HBB, that encodes a different… CONTINUE READING
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